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Iron‐Catalyzed Stereoselective Cross‐Coupling Reactions of Stereodefined Enol Carbamates with Grignard Reagents
Author(s) -
Rivera Ana Cristina Parra,
Still Raymond,
Frantz Doug E.
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201601899
Subject(s) - stereoselectivity , enol , reagent , chemistry , catalysis , yield (engineering) , coupling reaction , combinatorial chemistry , grignard reaction , organic chemistry , materials science , metallurgy
A practical and highly stereoselective iron‐catalyzed cross‐coupling reaction of stereodefined enol carbamates and Grignard reagents to yield tri‐ and tetrasubstituted acrylates is reported. A facile method for the stereoselective generation of these enol carbamates has also been developed.