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Palladium(0)‐Catalyzed Intermolecular Carbocyclization of (1, n )‐Diynes and Bromophenols: An Efficient Route to Tricyclic Scaffolds
Author(s) -
Bai Lu,
Yuan Yini,
Liu Jingjing,
Wu Jiaoyu,
Han Lingbo,
Wang Hui,
Wang Yaoyu,
Luan Xinjun
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201601570
Subject(s) - tricyclic , palladium , enantioselective synthesis , catalysis , chemistry , combinatorial chemistry , intermolecular force , substrate (aquarium) , functional group , stereochemistry , organic chemistry , molecule , biology , polymer , ecology
A novel palladium(0)‐catalyzed dearomative cyclization reaction of bromophenols with (1, n )‐diynes has been developed for building two new types of tricyclic architectures containing a quaternary carbon center. This method employs inexpensive bromophenols, and easily accessible tethered diynes. It exhibits a broad substrate scope and tolerates various functional groups. Preliminary results with commercially available chiral ligands indicate that enantioselective variants are feasible for both cyclization processes.