Nickel‐Catalyzed Difluoroalkylation of (Hetero)Arylborons with Unactivated 1‐Bromo‐1,1‐difluoroalkanes | Zendy

Xiao YuLan | Zendy; Min QiaoQiao | Zendy; Xu Chang | Zendy; Wang RuoWen | Zendy; Zhang Xingang | Zendy

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Nickel‐Catalyzed Difluoroalkylation of (Hetero)Arylborons with Unactivated 1‐Bromo‐1,1‐difluoroalkanes

Author(s) -

Xiao YuLan,

Min QiaoQiao,

Xu Chang,

Wang RuoWen,

Zhang Xingang

Publication year - 2016

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201601351

Subject(s) - nickel , denticity , catalysis , pyridine , chemistry , ligand (biochemistry) , bipyridine , combinatorial chemistry , medicinal chemistry , organic chemistry , crystal structure , receptor , biochemistry

A nickel‐catalyzed cross‐coupling between (hetero)arylborons and unactivated 1‐bromo‐1,1‐difluoroalkanes has been developed. The use of two ligands (a bidentate bipyridine‐based ligand, 4,4′‐ditBu‐bpy, and a monodentate pyridine‐based ligand, DMAP) offers a highly efficient nickel‐based catalytic system to prepare difluoroalkylated arenes which have important applications in medicinal chemistry.

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