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Nickel‐Catalyzed Stereoselective Dicarbofunctionalization of Alkynes
Author(s) -
Li Zhaodong,
GarcíaDomínguez Andrés,
Nevado Cristina
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201601296
Subject(s) - chemistry , aryl , catalysis , alkyl , stereoselectivity , reagent , nickel , halide , functional group , combinatorial chemistry , organic chemistry , polymer
A nickel‐catalyzed three‐component reaction involving terminal alkynes, boronic acids, and alkyl halides is presented herein. Trisubstituted alkenes can be obtained in a highly regio‐ and stereocontrolled manner by the simultaneous addition of both aryl and alkyl groups across the triple bond in a radical‐mediated process. The reaction, devoid of air‐ and moisture‐sensitive organometallic reagents and catalysts, is operationally simple and offers a broad scope and functional‐group tolerance.