Intra‐ and Intermolecular Nickel‐Catalyzed Reductive Cross‐Electrophile Coupling Reactions of Benzylic Esters with Aryl Halides | Zendy

Konev Mikhail O. | Zendy; Hanna Luke E. | Zendy; Jarvo Elizabeth R. | Zendy

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Intra‐ and Intermolecular Nickel‐Catalyzed Reductive Cross‐Electrophile Coupling Reactions of Benzylic Esters with Aryl Halides

Author(s) -

Konev Mikhail O.,

Hanna Luke E.,

Jarvo Elizabeth R.

Publication year - 2016

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201601206

Subject(s) - electrophile , aryl , chemistry , intramolecular force , halide , catalysis , coupling reaction , nickel , intermolecular force , stereospecificity , medicinal chemistry , combinatorial chemistry , organic chemistry , alkyl , molecule

Nickel‐catalyzed cross‐electrophile coupling reactions of benzylic esters and aryl halides have been developed. Both inter‐ and intramolecular variants proceed under mild reaction conditions. A range of heterocycles and functional groups are tolerated under the reaction conditions. Additionally, the first example of a stereospecific cross‐electrophile coupling of a secondary benzylic ester is described.

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