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Palladium‐Catalyzed Carbonylative Four‐Component Synthesis of Thiochromenones: The Advantages of a Reagent Capsule
Author(s) -
Shen Chaoren,
Spannenberg Anke,
Wu XiaoFeng
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201600953
Subject(s) - reagent , catalysis , palladium , chemistry , combinatorial chemistry , selectivity , reactivity (psychology) , capsule , organic chemistry , medicine , botany , alternative medicine , pathology , biology
Multicomponent reactions, especially those involving four or even more reagents, have been a long‐standing challenge because of the issues associated with balancing reactivity, selectivity, and compatibility. Herein, we demonstrate how the use of a reagent capsule provides straightforward access to synthetically valuable thiochromenone derivatives by a palladium‐catalyzed carbonylative four‐component reaction. To the best of our knowledge, this is the first example of applying a capsule to prevent catalyst poisoning and undesired side reactions of the multicomponent reaction.