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Self‐Assembly of Multi‐nanozymes to Mimic an Intracellular Antioxidant Defense System
Author(s) -
Huang Yanyan,
Liu Zhen,
Liu Chaoqun,
Ju Enguo,
Zhang Yan,
Ren Jinsong,
Qu Xiaogang
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201600868
Subject(s) - intracellular , superoxide dismutase , chemistry , antioxidant , reactive oxygen species , catalase , glutathione peroxidase , oxidative stress , biophysics , nanomaterials , glutathione , biochemistry , microbiology and biotechnology , nanotechnology , enzyme , materials science , biology
In this work, for the first time, we constructed a novel multi‐nanozymes cooperative platform to mimic intracellular antioxidant enzyme‐based defense system. V 2 O 5 nanowire served as a glutathione peroxidase (GPx) mimic while MnO 2 nanoparticle was used to mimic superoxide dismutase (SOD) and catalase (CAT). Dopamine was used as a linker to achieve the assembling of the nanomaterials. The obtained V 2 O 5 @pDA@MnO 2 nanocomposite could serve as one multi‐nanozyme model to mimic intracellular antioxidant enzyme‐based defense procedure in which, for example SOD, CAT, and GPx co‐participate. In addition, through assembling with dopamine, the hybrid nanocomposites provided synergistic antioxidative effect. Importantly, both in vitro and in vivo experiments demonstrated that our biocompatible system exhibited excellent intracellular reactive oxygen species (ROS) removal ability to protect cell components against oxidative stress, showing its potential application in inflammation therapy.