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Readily Accessible Bulky Iron Catalysts exhibiting Site Selectivity in the Oxidation of Steroidal Substrates
Author(s) -
Font David,
Canta Mercè,
Milan Michela,
Cussó Olaf,
Ribas Xavi,
Klein Gebbink Robertus J. M.,
Costas Miquel
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201600785
Subject(s) - steric effects , chemistry , catalysis , selectivity , hydrogen peroxide , alkyl , hydrogen bond , redox , photochemistry , active site , combinatorial chemistry , organic chemistry , molecule
Bulky iron complexes are described that catalyze the site‐selective oxidation of alkyl C−H bonds with hydrogen peroxide under mild conditions. Steric bulk at the iron center is introduced by appending trialkylsilyl groups at the meta ‐position of the pyridines in tetradentate aminopyridine ligands, and this effect translates into high product yields, an enhanced preferential oxidation of secondary over tertiary C−H bonds, and the ability to perform site‐selective oxidation of methylenic sites in terpenoid and steroidal substrates. Unprecedented site selective oxidation at C6 and C12 methylenic sites in steroidal substrates is shown to be governed by the chirality of the catalysts.