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H 2 ‐Fueled ATP Synthesis on an Electrode: Mimicking Cellular Respiration
Author(s) -
GutiérrezSanz Óscar,
Natale Paolo,
Márquez Ileana,
Marques Marta C.,
Zacarias Sonia,
Pita Marcos,
Pereira Inês A. C.,
LópezMontero Iván,
De Lacey Antonio L.,
Vélez Marisela
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201600752
Subject(s) - atp synthase , atpase , electrochemistry , chemistry , electrode , electrochemical gradient , hydrogenase , chemiosmosis , adenosine triphosphate , biophysics , enzyme , cellular respiration , biochemistry , membrane , mitochondrion , biology
ATP, the molecule used by living organisms to supply energy to many different metabolic processes, is synthesized mostly by the ATPase synthase using a proton or sodium gradient generated across a lipid membrane. We present evidence that a modified electrode surface integrating a NiFeSe hydrogenase and a F 1 F 0 ‐ATPase in a lipid membrane can couple the electrochemical oxidation of H 2 to the synthesis of ATP. This electrode‐assisted conversion of H 2 gas into ATP could serve to generate this biochemical fuel locally when required in biomedical devices or enzymatic synthesis of valuable products.