Ruthenium‐Catalyzed Hydroarylation and One‐Pot Twofold Unsymmetrical C−H Functionalization of Arenes | Zendy

Ghosh Koushik | Zendy; Rit Raja K. | Zendy; Ramesh E. | Zendy; Sahoo Akhila K. | Zendy

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Ruthenium‐Catalyzed Hydroarylation and One‐Pot Twofold Unsymmetrical C−H Functionalization of Arenes

Author(s) -

Ghosh Koushik,

Rit Raja K.,

Ramesh E.,

Sahoo Akhila K.

Publication year - 2016

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201600649

Subject(s) - intramolecular force , surface modification , chemistry , ruthenium , catalysis , alkene , intermolecular force , combinatorial chemistry , benzoic acid , medicinal chemistry , stereochemistry , molecule , organic chemistry

A methyl phenyl sulfoximine (MPS) is used as a directing group in the ruthenium‐catalyzed intramolecular hydroarylation of alkene‐tethered benzoic acid derivatives to afford dihydrobenzofurans and indolines in good to excellent yields. A one‐pot, unsymmetrical, twofold C−H functionalization involving intramolecular C−C and intermolecular C−C/C−N bond formations is successfully demonstrated by using a single set of catalytic reaction conditions, which is unprecedented thus far. A novel isoquinolone‐bearing dihydrobenzofuran is constructed through an unsymmetrical twofold C−H functionalization.

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