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Ruthenium‐Catalyzed Hydroarylation and One‐Pot Twofold Unsymmetrical C−H Functionalization of Arenes
Author(s) -
Ghosh Koushik,
Rit Raja K.,
Ramesh E.,
Sahoo Akhila K.
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201600649
Subject(s) - intramolecular force , surface modification , chemistry , ruthenium , catalysis , alkene , intermolecular force , combinatorial chemistry , benzoic acid , medicinal chemistry , stereochemistry , molecule , organic chemistry
A methyl phenyl sulfoximine (MPS) is used as a directing group in the ruthenium‐catalyzed intramolecular hydroarylation of alkene‐tethered benzoic acid derivatives to afford dihydrobenzofurans and indolines in good to excellent yields. A one‐pot, unsymmetrical, twofold C−H functionalization involving intramolecular C−C and intermolecular C−C/C−N bond formations is successfully demonstrated by using a single set of catalytic reaction conditions, which is unprecedented thus far. A novel isoquinolone‐bearing dihydrobenzofuran is constructed through an unsymmetrical twofold C−H functionalization.