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Total Synthesis of Cryptocaryol A by Enantioselective Iridium‐Catalyzed Alcohol C−H Allylation
Author(s) -
Perez Felix,
Waldeck Andrew R.,
Krische Michael J.
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201600591
Subject(s) - enantioselective synthesis , iridium , polyketide , total synthesis , chemistry , alcohol , catalysis , natural product , diol , stereochemistry , combinatorial chemistry , organic chemistry , enzyme , biosynthesis
The polyketide natural product cryptocaryol A is prepared in 8 steps via iridium catalyzed enantioselective diol double C−H allylation, which directly generates an acetate‐based triketide stereodiad. In 4 previously reported total syntheses, 17–28 steps were required.