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Nanotexaphyrin: One‐Pot Synthesis of a Manganese Texaphyrin‐Phospholipid Nanoparticle for Magnetic Resonance Imaging
Author(s) -
Keca Joseph M.,
Chen Juan,
Overchuk Marta,
Muhanidal,
MacLaughlin Christina M.,
Jin Cheng S.,
Foltz Warren D.,
Irish Jonathan C.,
Zheng Gang
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201600234
Subject(s) - nanoparticle , manganese , nanotechnology , magnetic resonance imaging , materials science , chemistry , magnetic nanoparticles , combinatorial chemistry , organic chemistry , medicine , radiology
The discovery and synthesis of novel multifunctional organic building blocks for nanoparticles is challenging. Texaphyrin macrocycles are capable and multifunctional chelators. However, they remain elusive as building blocks for nanoparticles because of the difficulty associated with synthesis of texaphyrin constructs capable of self‐assembly. A novel manganese (Mn)‐texaphyrin‐phospholipid building block is described, along with its one‐pot synthesis and self‐assembly into a Mn‐nanotexaphyrin. This nanoparticle possesses strong resilience to manganese dissociation, structural stability, in vivo bio‐safety, and structure‐dependent T 1 and T 2 relaxivities. Magnetic resonance imaging (MRI) contrast enhanced visualization of lymphatic drainage is demonstrated with respect to proximal lymph nodes on the head and neck VX‐2 tumors of a rabbit. Synthesis of 17 additional metallo‐texaphyrin building blocks suggests that this novel one‐pot synthetic procedure for nanotexaphyrins may lead to a wide range of applications in the field of nanomedicines.