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Synthesis of Aryldifluoroamides by Copper‐Catalyzed Cross‐Coupling
Author(s) -
Arlow Sophie I.,
Hartwig John F.
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201600105
Subject(s) - aryl , steric effects , copper , catalysis , chemistry , yield (engineering) , combinatorial chemistry , coupling reaction , coupling (piping) , organic chemistry , materials science , alkyl , metallurgy
Abstract A copper‐catalyzed coupling of aryl, heteroaryl, and vinyl iodides with α‐silyldifluoroamides is reported. The reaction forms α,α‐difluoro‐α‐aryl amides from electron‐rich, electron‐poor, and sterically hindered aryl iodides in high yield and tolerates a variety of functional groups. The aryldifluoroamide products can be transformed further to provide access to a diverse array of difluoroalkylarenes, including compounds of potential biological interest.