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Asymmetric Synthesis of Axinellamines A and B
Author(s) -
Ma Zhiqiang,
Wang Xiao,
Ma Yuyong,
Chen Chuo
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201600007
Subject(s) - imidazole , chemistry , sponge , pyrrole , biomimetic synthesis , stereochemistry , oxidative phosphorylation , broad spectrum , combinatorial chemistry , organic chemistry , biochemistry , biology , botany
Axinellamines A and B are broad‐spectrum antibacterial pyrrole–imidazole alkaloids that have a complex polycyclic skeleton. A new asymmetric synthesis of these marine sponge metabolites is described herein, featuring an oxidative rearrangement and an anchimeric chlorination reaction.