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Arsenic‐Containing Phosphatidylcholines: A New Group of Arsenolipids Discovered in Herring Caviar
Author(s) -
Viczek Sandra A.,
Jensen Kenneth B.,
Francesconi Kevin A.
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201512031
Subject(s) - arsenic , chemistry , phosphatidylethanolamine , phosphatidylcholine , herring , mass spectrometry , fish <actinopterygii> , membrane , biochemistry , stereochemistry , organic chemistry , chromatography , phospholipid , fishery , biology
A new group of arsenolipids based on cell‐membrane phosphatidylcholines has been discovered in herring caviar (fish roe). A combination of HPLC with elemental and molecular mass spectrometry was used to identify five arsenic‐containing phosphatidylcholines; the same technique applied to salmon caviar identified an arsenic‐containing phosphatidylethanolamine. The arsenic group in these membrane lipids might impart particular properties to the molecules not displayed by their non‐arsenic analogues. Additionally, the new compounds have human health implications according to recent results showing high cytotoxicity for some arsenolipids.