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Anisotropic Self‐Assembly of Citrate‐Coated Gold Nanoparticles on Fluidic Liposomes
Author(s) -
Sugikawa Kouta,
Kadota Tatsuya,
Yasuhara Kazuma,
Ikeda Atsushi
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201511785
Subject(s) - liposome , nanoparticle , self assembly , membrane , nanotechnology , colloidal gold , chemical engineering , fluidics , chemistry , phospholipid , materials science , aerospace engineering , engineering , biochemistry
The behavior of self‐assembly processes of nanoscale particles on plasma membranes can reveal mechanisms of important biofunctions and/or intractable diseases. Self‐assembly of citrate‐coated gold nanoparticles (cAuNPs) on liposomes was investigated. The adsorbed cAuNPs were initially fixed on the liposome surfaces and did not self‐assemble below the phospholipid phase transition temperature ( T m ). In contrast, anisotropic cAuNP self‐assembly was observed upon heating of the composite above the T m , where the phospholipids became fluid. The number of self‐assembled NPs is conveniently controlled by the initial mixing ratio of cAuNPs and liposomes. Gold nanoparticle protecting agents strongly affected the self‐assembly process on the fluidic membrane.