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Basic Physicochemical Properties of Polyethylene Glycol Coated Gold Nanoparticles that Determine Their Interaction with Cells
Author(s) -
del Pino Pablo,
Yang Fang,
Pelaz Beatriz,
Zhang Qian,
Kantner Karsten,
Hartmann Raimo,
Martinez de Baroja Natalia,
Gallego Marta,
Möller Marco,
Manshian Bella B.,
Soenen Stefaan J.,
Riedel René,
Hampp Norbert,
Parak Wolfgang J.
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201511733
Subject(s) - polyethylene glycol , nanoparticle , colloidal gold , polymer , surface modification , chemical engineering , polyethylene , materials science , chemistry , nanotechnology , polymer chemistry , organic chemistry , engineering
A homologous nanoparticle library was synthesized in which gold nanoparticles were coated with polyethylene glycol, whereby the diameter of the gold cores, as well as the thickness of the shell of polyethylene glycol, was varied. Basic physicochemical parameters of this two‐dimensional nanoparticle library, such as size, ζ‐potential, hydrophilicity, elasticity, and catalytic activity ,were determined. Cell uptake of selected nanoparticles with equal size yet varying thickness of the polymer shell and their effect on basic structural and functional cell parameters was determined. Data indicates that thinner, more hydrophilic coatings, combined with the partial functionalization with quaternary ammonium cations, result in a more efficient uptake, which relates to significant effects on structural and functional cell parameters.