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Enantioselective Synthesis of Silacyclopentanes
Author(s) -
Igawa Kazunobu,
Yoshihiro Daisuke,
Abe Yusuke,
Tomooka Katsuhiko
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201511728
Subject(s) - enantioselective synthesis , stereospecificity , chemistry , combinatorial chemistry , stereochemistry , catalysis , in vitro , organic chemistry , biochemistry
Abstract A variety of functionalized silacyclopentanes were synthesized by highly enantioselective β‐eliminations of silacyclopentene oxides followed by stereospecific transformations. The reaction mechanism of the β‐elimination was elucidated by DFT calculations. An in vitro biological assay with an oxy‐functionalized silacyclopentane showed substantial binding to a serotonin receptor protein.