Premium
Nickel‐Catalyzed Decarboxylative Difluoroalkylation of α,β‐Unsaturated Carboxylic Acids
Author(s) -
Li Gang,
Wang Tao,
Fei Fan,
Su YiMing,
Li Yan,
Lan Quan,
Wang XiSheng
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201511321
Subject(s) - catalysis , chemistry , nickel , substrate (aquarium) , halide , catalytic cycle , decarboxylation , stereoselectivity , functional group , organic chemistry , carboxylic acid , combinatorial chemistry , polymer , oceanography , geology
Abstract The first example of nickel‐catalyzed decarboxylative fluoroalkylation of α,β‐unsaturated carboxylic acids has been developed with commonly available fluoroalkyl halides. This novel transformation has demonstrated broad substrate scope, excellent functional‐group tolerance, mild reaction conditions, and excellent stereoselectivity. Mechanistic investigations indicate that a fluoroalkyl radical is involved in the catalytic cycle.