Premium
Polyoxometalate‐Driven Self‐Assembly of Short Peptides into Multivalent Nanofibers with Enhanced Antibacterial Activity
Author(s) -
Li Jingfang,
Chen Zhijun,
Zhou Mengcheng,
Jing Jiangbo,
Li Wen,
Wang Yang,
Wu Lixin,
Wang Liyan,
Wang Yanqiu,
Lee Myongsoo
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201511276
Subject(s) - nanofiber , polyoxometalate , self assembly , peptide , chemistry , nanotechnology , combinatorial chemistry , materials science , biochemistry , catalysis
Multivalent peptide nanofibers have attracted intense attention as promising platforms, but the fabrication of those nanofibers is mainly dependent on the spontaneous assembly of β‐sheet peptides. Herein we report an alternative approach to the creation of nanofibers: the polyoxometalate‐driven self‐assembly of short peptides. The resultant nanofibers with concentrated positive charges are excellent multivalent ligands for binding with bacterial cells and thus lead to a salient improvement in bioactivity.