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Reductive Cyclopropanations Catalyzed by Dinuclear Nickel Complexes
Author(s) -
Zhou YouYun,
Uyeda Christopher
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201511271
Subject(s) - cyclopropanation , carbene , cyclopropane , catalysis , methylene , chemistry , diimine , reductive elimination , nickel , medicinal chemistry , combinatorial chemistry , organic chemistry , photochemistry , ring (chemistry)
Dinuclear Ni complexes supported by naphthyridine‐diimine (NDI) ligands catalyze the reductive cyclopropanation of alkenes with CH 2 Cl 2 as the methylene source. The use of mild terminal reductants (Zn or Et 2 Zn) confers significant functional‐group tolerance, and the catalyst accommodates structurally and electronically diverse alkenes. Mononickel catalysts bearing related N chelates afford comparatively low cyclopropane yields (≤20 %). These results constitute an entry into catalytic carbene transformations from oxidized methylene precursors.