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A Shape‐Memory DNA‐Based Hydrogel Exhibiting Two Internal Memories
Author(s) -
Hu Yuwei,
Guo Weiwei,
Kahn Jason S.,
AlemanGarcia Miguel Angel,
Willner Itamar
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201511201
Subject(s) - dissociation (chemistry) , chemistry , oligonucleotide , dna , self healing hydrogels , shape memory alloy , crystallography , materials science , polymer chemistry , organic chemistry , composite material , biochemistry
The synthesis of a shape‐memory acrylamide–DNA hydrogel that includes two internal memories is introduced. The hydrogel is stabilized, at pH 7.0, by two different pH‐responsive oligonucleotide crosslinking units. At pH 10.0, one of the T‐A⋅T triplex DNA bridging units is dissociated, resulting in the dissociation of the hydrogel into a shapeless quasi‐liquid state that includes the other oligonucleotide bridges as internal memory. Similarly, at pH 5.0, the second type of bridges is separated, through the formation of C‐G⋅C + triplex units to yield the shapeless quasi‐liquid state that includes the other oligonucleotide bridges as internal memory. By reversible pH triggering of the hydrogel between the values 10.0⇔7.0⇔5.0, the two internal memories cycle the material across shaped hydrogel and shapeless quasi‐liquid states. The two memories enable the pH‐dictated formation of two different hydrogel structures.