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Stretch‐Induced Drug Delivery from Superhydrophobic Polymer Composites: Use of Crack Propagation Failure Modes for Controlling Release Rates
Author(s) -
Wang Julia,
Kaplan Jonah A.,
Colson Yolonda L.,
Grinstaff Mark W.
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201511052
Subject(s) - materials science , composite material , polymer , drug delivery , biodegradable polymer , polyester , polylactic acid , coating , caprolactone , polymerization , chemical engineering , nanotechnology , engineering
The concept of using crack propagation in polymeric materials to control drug release and its first demonstration are reported. The composite drug delivery system consists of highly‐textured superhydrophobic electrosprayed microparticle coatings, composed of biodegradable and biocompatible polymers poly(caprolactone) and poly(glycerol monostearate carbonate‐co‐caprolactone), and a cellulose/polyester core. The release of entrapped agents is controlled by the magnitude of applied strain, resulting in a graded response from water infiltration through the propagating patterned cracks in the coating. Strain‐dependent delivery of the anticancer agents cisplatin and 7‐ethyl‐10‐hydroxycamptothecin to esophageal cancer cells (OE33) in vitro is observed. Finally the device is integrated with an esophageal stent to demonstrate delivery of fluorescein diacetate, using applied tension, to an ex vivo esophagus.