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Framework Cationization by Preemptive Coordination of Open Metal Sites for Anion‐Exchange Encapsulation of Nucleotides and Coenzymes
Author(s) -
Zhao Xiang,
Mao Chengyu,
Luong Karen Tu,
Lin Qipu,
Zhai QuanGuo,
Feng Pingyun,
Bu Xianhui
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201510812
Subject(s) - cationic polymerization , chemistry , metal organic framework , ion exchange , cofactor , nucleotide , combinatorial chemistry , metal , ion , inorganic chemistry , organic chemistry , adsorption , biochemistry , gene , enzyme
Cationic frameworks can selectively trap anions through ion exchange, and have applications in ion chromatography and drug delivery. However, cationic frameworks are much rarer than anionic or neutral ones. Herein, we propose a concept, preemptive coordination (PC), for targeting positively charged metal–organic frameworks (P‐MOFs). PC refers to proactive blocking of metal coordination sites to preclude their occupation by neutralizing ligands such as OH − . We use 20 MOFs to show that this PC concept is an effective approach for developing P‐MOFs whose high stability, porosity, and anion‐exchange capability allow immobilization of anionic nucleotides and coenzymes, in addition to charge‐ and size‐selective capture or separation of organic dyes. The CO 2 and C 2 H 2 uptake capacity of 117.9 cm 3 g −1 and 148.5 cm 3 g −1 , respectively, at 273 K and 1 atm, is exceptionally high among cationic framework materials.