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Total Synthesis of (±)‐Alstoscholarisine A
Author(s) -
Bihelovic Filip,
Ferjancic Zorana
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201510777
Subject(s) - total synthesis , domino , nonane , chemistry , stereochemistry , sequence (biology) , indole test , combinatorial chemistry , organic chemistry , biochemistry , catalysis
The first total synthesis of the neuroactive indole alkaloid (±)‐alstoscholarisine A is reported. The key step of the concise synthesis is an efficient domino sequence that was used to assemble the 2,8‐diazabicyclo[3.3.1]nonane core through the formation of two C−N bonds and one C−C bond in a single step.