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Practical Direct α‐Arylation of Cyclopentanones by Palladium/Enamine Cooperative Catalysis
Author(s) -
Xu Yan,
Su Tianshun,
Huang Zhongxing,
Dong Guangbin
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201510638
Subject(s) - palladium , enamine , chemistry , aryl , aldol reaction , amine gas treating , catalysis , functional group , aldol condensation , combinatorial chemistry , organic chemistry , alkyl , polymer
Direct arylation of cyclopentanones has been a long‐standing challenge because of competitive self‐aldol condensation and multiple arylations. Reported herein is a direct mono‐α‐C−H arylation of cyclopentanones with aryl bromides which is enabled by palladium/amine cooperative catalysis. This method is scalable and chemoselective with broad functional‐group tolerance. Application to controlled sequential arylation of cyclopentanones has been also demonstrated.