Solid‐State NMR of PEGylated Proteins | Zendy

Ravera Enrico | Zendy; Ciambellotti Silvia | Zendy; Cerofolini Linda | Zendy; Martelli Tommaso | Zendy; Kozyreva Tatiana | Zendy; Bernacchioni Caterina | Zendy; Giuntini Stefano | Zendy; Fragai Marco | Zendy; Turano Paola | Zendy; Luchinat Claudio | Zendy

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Solid‐State NMR of PEGylated Proteins

Author(s) -

Ravera Enrico,

Ciambellotti Silvia,

Cerofolini Linda,

Martelli Tommaso,

Kozyreva Tatiana,

Bernacchioni Caterina,

Giuntini Stefano,

Fragai Marco,

Turano Paola,

Luchinat Claudio

Publication year - 2016

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201510148

Subject(s) - chemistry , solid state nuclear magnetic resonance , biomedicine , nuclear magnetic resonance spectroscopy , characterization (materials science) , nanotechnology , computational biology , materials science , nuclear magnetic resonance , bioinformatics , organic chemistry , biology , physics

PEGylated proteins are widely used in biomedicine but, in spite of their importance, no atomic‐level information is available since they are generally resistant to structural characterization approaches. PEGylated proteins are shown here to yield highly resolved solid‐state NMR spectra, which allows assessment of the structural integrity of proteins when PEGylated for therapeutic or diagnostic use.

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