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Synthesis of Iron Nanometallic Glasses and Their Application in Cancer Therapy by a Localized Fenton Reaction
Author(s) -
Zhang Chen,
Bu Wenbo,
Ni Dalong,
Zhang Shenjian,
Li Qing,
Yao Zhenwei,
Zhang Jiawen,
Yao Heliang,
Wang Zheng,
Shi Jianlin
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201510031
Subject(s) - disproportionation , ferrous , cancer therapy , nanocrystal , fenton reaction , nanoparticle , materials science , amorphous solid , nanotechnology , cancer , chemistry , chemical engineering , combinatorial chemistry , catalysis , metallurgy , organic chemistry , medicine , engineering
Metallic glasses and cancer theranostics are emerging fields that do not seem to be related to each other. Herein, we report the facile synthesis of amorphous iron nanoparticles (AFeNPs) and their superior physicochemical properties compared to their crystalline counterpart, iron nanocrystals (FeNCs). The AFeNPs can be used for cancer theranostics by inducing a Fenton reaction in the tumor by taking advantage of the mild acidity and the overproduced H 2 O 2 in a tumor microenvironment: Ionization of the AFeNPs enables on‐demand ferrous ion release in the tumor, and subsequent H 2 O 2 disproportionation leads to efficient . OH generation. The endogenous stimuli‐responsive . OH generation in the presence AFeNPs enables a highly specific cancer therapy without the need for external energy input.