Premium
Synthesis and Utility of Dihydropyridine Boronic Esters
Author(s) -
Panda Santanu,
Coffin Aaron,
Nguyen Q. Nhu,
Tantillo Dean J.,
Ready Joseph M.
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201510027
Subject(s) - pyridine , chemistry , dihydropyridine , piperidine , reagent , combinatorial chemistry , organic chemistry , calcium
Abstract When activated by an acylating agent, pyridine boronic esters react with organometallic reagents to form a dihydropyridine boronic ester. This intermediate allows access to a number of valuable substituted pyridine, dihydropyridine, and piperidine products.