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Ligand‐Promoted Borylation of C(sp 3 )H Bonds with Palladium(II) Catalysts
Author(s) -
He Jian,
Jiang Heng,
Takise Ryosuke,
Zhu RuYi,
Chen Gang,
Dai HuiXiong,
Dhar T. G. Murali,
Shi Jun,
Zhang Hao,
Cheng Peter T. W.,
Yu JinQuan
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201509996
Subject(s) - borylation , chemistry , palladium , cyclopentanes , rhodium , ligand (biochemistry) , catalysis , iridium , medicinal chemistry , quinoline , combinatorial chemistry , stereochemistry , organic chemistry , aryl , biochemistry , alkyl , receptor
A quinoline‐based ligand effectively promotes the palladium‐catalyzed borylation of C(sp 3 )H bonds. Primary β‐C(sp 3 )H bonds in carboxylic acid derivatives as well as secondary C(sp 3 )H bonds in a variety of carbocyclic rings, including cyclopropanes, cyclobutanes, cyclopentanes, cyclohexanes, and cycloheptanes, can thus be borylated. This directed borylation method complements existing iridium(I)‐ and rhodium(I)‐catalyzed CH borylation reactions in terms of scope and operational conditions.