Synthesis of Multiply Substituted Polycyclic Aromatic Hydrocarbons by Iridium‐Catalyzed Annulation of Ring‐Fused Benzocyclobutenol with Alkyne through C−C Bond Cleavage | Zendy

Yu Jiajia | Zendy; Yan Hong | Zendy; Zhu Chen | Zendy

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Synthesis of Multiply Substituted Polycyclic Aromatic Hydrocarbons by Iridium‐Catalyzed Annulation of Ring‐Fused Benzocyclobutenol with Alkyne through C−C Bond Cleavage

Author(s) -

Yu Jiajia,

Yan Hong,

Zhu Chen

Publication year - 2016

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201509973

Subject(s) - annulation , chemistry , alkyne , iridium , catalysis , bond cleavage , ring (chemistry) , cleavage (geology) , medicinal chemistry , stereochemistry , organic chemistry , materials science , fracture (geology) , composite material

The first iridium‐catalyzed intermolecular cyclization between alkynes and ring‐fused benzocyclobutenols (RBCB) through C−C bond cleavage is described. A variety of elusive polycyclic aromatic hydrocarbons (PAHs) with multiple substituents are obtained in good yields under mild conditions. This procedure provides a unique and expeditious tool for the synthesis of PAHs.

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