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Reaction of Diazo Compounds with Difluorocarbene: An Efficient Approach towards 1,1‐Difluoroolefins
Author(s) -
Zhang Zhikun,
Yu Weizhi,
Wu Chenggui,
Wang Chengpeng,
Zhang Yan,
Wang Jianbo
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201509711
Subject(s) - difluorocarbene , carbene , diazo , bromide , chemistry , transition metal , combinatorial chemistry , photochemistry , organic chemistry , catalysis
A transition‐metal‐free difluoromethylenation of diazo compounds that proceeds under mild conditions has been developed and is based on the use of TMSCF 2 Br as the difluoromethylene source and tetrabutylammonium bromide (TBAB) as the promoter. The chemoselective formal carbene dimerization reaction is achieved owing to the electronic properties and the relative stability of the difluorocarbene intermediate.