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Ruthenium(0)‐Catalyzed [4+2] Cycloaddition of Acetylenic Aldehydes with α‐Ketols: Convergent Construction of Angucycline Ring Systems
Author(s) -
Saxena Aakarsh,
Perez Felix,
Krische Michael J.
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201509646
Subject(s) - ruthenium , chemistry , ring (chemistry) , cycloaddition , catalysis , diastereomer , medicinal chemistry , stereochemistry , organic chemistry
Ruthenium(0) complexes modified by CyJohnPhos or RuPhos catalyze the successive C−C coupling of acetylenic aldehydes with α‐ketols to form [4+2] cycloadducts as single diastereomers. This method enables convergent construction of type II polyketide ring systems of the angucycline class.
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