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An Improved System for the Aqueous Lipshutz–Negishi Cross‐Coupling of Alkyl Halides with Aryl Electrophiles
Author(s) -
Bhonde Vasudev R.,
O'Neill Brian T.,
Buchwald Stephen L.
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201509341
Subject(s) - negishi coupling , alkyl , chemistry , aryl , phosphine , halide , electrophile , alkylation , reagent , ligand (biochemistry) , aqueous solution , zinc , catalysis , combinatorial chemistry , organic chemistry , biochemistry , receptor
The development of a palladacyclic precatalyst supported by a new biaryl(dialkyl)phosphine ligand (VPhos) in combination with octanoic acid/sodium octanoate as a simple and effective surfactant system provided an improved catalyst system for the rapid construction of a broad spectrum of alkylated scaffolds from alkyl zinc reagents generated in situ.