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Visible‐Light‐Induced Hydrodifluoromethylation of Alkenes with a Bromodifluoromethylphosphonium Bromide
Author(s) -
Lin QingYu,
Xu XiuHua,
Zhang Ke,
Qing FengLing
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201509282
Subject(s) - difluorocarbene , bromide , reagent , hydrogen bromide , photochemistry , chemistry , visible spectrum , organic chemistry , combinatorial chemistry , bromine , materials science , optoelectronics
Bromodifluoromethylphosphonium bromide was solely used as the precursor of difluorocarbene. Herein, an unprecedented visible‐light‐induced hydrodifluoromethylation of alkenes with bromodifluoromethylphosphonium bromide using H 2 O and THF as hydrogen sources for the synthesis of difluoromethylated alkanes is described. This difluoromethylation is characterized by mild reaction conditions, ready availability of reagents, and excellent functional‐group tolerance.