Premium
Ligand‐Enabled Catalytic CH Arylation of Aliphatic Amines by a Four‐Membered‐Ring Cyclopalladation Pathway
Author(s) -
He Chuan,
Gaunt Matthew J.
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201508912
Subject(s) - chemistry , ligand (biochemistry) , ring (chemistry) , palladium , catalysis , molecule , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , receptor , biochemistry
A palladium‐catalyzed CH arylation of aliphatic amines with arylboronic esters is described, proceeding through a four‐membered‐ring cyclopalladation pathway. Crucial to the successful outcome of this reaction is the action of an amino‐acid‐derived ligand. A range of hindered secondary amines and arylboronic esters are compatible with this process and the products of the arylation can be advanced to complex polycyclic molecules by sequential CH activation reactions.