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Visible‐Light‐Triggered Drug Release from TiO 2 Nanotube Arrays: A Controllable Antibacterial Platform
Author(s) -
Xu Jingwen,
Zhou Xuemei,
Gao Zhida,
Song YanYan,
Schmuki Patrik
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201508710
Subject(s) - visible spectrum , photocatalysis , nanotube , materials science , drug delivery , nanotechnology , nanoparticle , chemical engineering , stack (abstract data type) , chemistry , carbon nanotube , catalysis , organic chemistry , optoelectronics , computer science , engineering , programming language
In this work, we use a double‐layered stack of TiO 2 nanotubes (TiNTs) to construct a visible‐light‐triggered drug delivery system. The key for visible light drug release is a hydrophobic cap on the nanotubes containing Au nanoparticles (AuNPs). The AuNPs allow for a photocatalytic scission of the hydrophobic chain under visible light. To demonstrate this principle, we loaded ampicillin (AMP) into the lower part of the TiO 2 nanotube stack, triggered visible‐light‐induced release, and carried out antibacterial studies. The release from the platform becomes most controllable if the drug is silane‐grafted in the hydrophilic bottom layer for drug storage. Thus, visible light photocatalysis can also determine the release kinetics of the active drug from the nanotube wall.