Premium
Splitting a Substrate into Three Parts: Gold‐Catalyzed Nitrogenation of Alkynes by CC and CC Bond Cleavage
Author(s) -
Qin Chong,
Su Yijin,
Shen Tao,
Shi Xiaodong,
Jiao Ning
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201508347
Subject(s) - chemoselectivity , catalysis , substrate (aquarium) , chemistry , bond cleavage , tetrazole , cleavage (geology) , combinatorial chemistry , stereochemistry , organic chemistry , materials science , oceanography , fracture (geology) , composite material , geology
Abstract A gold‐catalyzed nitrogenation of alkynes for the synthesis of carbamides and amino tetrazoles through CC and CC bond cleavages is described. A diverse set of functionalized carbamide and amino tetrazole derivatives were selectively constructed under mild conditions. The chemoselectivity can be easily switched by the selection of the acid additives. The reaction is characterized by its broad substrate scope, direct construction of high value products, easy operation under air, and mild conditions at room temperature. This chemistry provides a way to transform alkynes by splitting the substrate into three parts.