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Cobalt‐Catalyzed Alkenylzincation of Unfunctionalized Alkynes
Author(s) -
Wu Junliang,
Yoshikai Naohiko
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201508262
Subject(s) - reagent , cobalt , catalysis , chemistry , stereoselectivity , transition metal , combinatorial chemistry , organic synthesis , organic chemistry , polymer chemistry
While transition metal catalyzed addition reactions of arylmetal reagents to unfunctionalized alkynes have been extensively developed in the last decade, analogous reactions using alkenylmetal reagents remain rare regardless of their potential utility for the synthesis of unsymmetrical 1,3‐dienes. Reported herein is the development of a cobalt/diphosphine catalyst which promotes efficient and stereoselective addition of alkenylzinc reagents to unfunctionalized internal alkynes. The resulting dienylzinc species serve as versatile intermediates for further synthetic transformations.

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