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N‐Heterocyclic Carbene Catalyzed Dynamic Kinetic Resolution of Pyranones
Author(s) -
Zhao Changgui,
Li Fangyi,
Wang Jian
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201508205
Subject(s) - carbene , kinetic resolution , chemistry , catalysis , redox , organic chemistry , organocatalysis , combinatorial chemistry , enantioselective synthesis
The dynamic kinetic resolution of 6‐hydroxypyranones with enals or alkynals through an asymmetric redox esterification is catalyzed by a chiral N‐heterocyclic carbene. The resulting esters are obtained in good to high yields and with high levels of enantio‐ and diastereocontrol. The reaction products are further derivatized to obtain functionalized sugar derivatives and natural products.