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High‐Resolution Crystal Structure of a Silver(I)–RNA Hybrid Duplex Containing Watson–Crick‐like CSilver(I)C Metallo‐Base Pairs
Author(s) -
Kondo Jiro,
Tada Yoshinari,
Dairaku Takenori,
Saneyoshi Hisao,
Okamoto Itaru,
Tanaka Yoshiyuki,
Ono Akira
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201507894
Subject(s) - base pair , molecular structure of nucleic acids: a structure for deoxyribose nucleic acid , duplex (building) , nucleobase , nucleic acid , crystal structure , dna , crystallography , chemistry , rna , pyrimidine , stereochemistry , base (topology) , gene , mathematics , biochemistry , mathematical analysis
Metallo‐base pairs have been extensively studied for applications in nucleic acid‐based nanodevices and genetic code expansion. Metallo‐base pairs composed of natural nucleobases are attractive because nanodevices containing natural metallo‐base pairs can be easily prepared from commercially available sources. Previously, we have reported a crystal structure of a DNA duplex containing THg II T base pairs. Herein, we have determined a high‐resolution crystal structure of the second natural metallo‐base pair between pyrimidine bases CAg I C formed in an RNA duplex. One Ag I occupies the center between two cytosines and forms a CAg I C base pair through N3Ag I N3 linear coordination. The CAg I C base pair formation does not disturb the standard A‐form conformation of RNA. Since the CAg I C base pair is structurally similar to the canonical Watson–Crick base pairs, it can be a useful building block for structure‐based design and fabrication of nucleic acid‐based nanodevices.