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A Case Study of the Likes and Dislikes of DNA and RNA in Self‐Assembly
Author(s) -
Zuo Hua,
Wu Siyu,
Li Mo,
Li Yulin,
Jiang Wen,
Mao Chengde
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201507375
Subject(s) - rna , dna , nucleic acid , self assembly , nanotechnology , chemistry , computational biology , biology , biochemistry , materials science , gene
Programmed self‐assembly of nucleic acids (DNA and RNA) is an active research area as it promises a general approach for nanoconstruction. Whereas DNA self‐assembly has been extensively studied, RNA self‐assembly lags much behind. One strategy to boost RNA self‐assembly is to adapt the methods of DNA self‐assembly for RNA self‐assembly because of the chemical and structural similarities of DNA and RNA. However, these two types of molecules are still significantly different. To enable the rational design of RNA self‐assembly, a thorough examination of their likes and dislikes in programmed self‐assembly is needed. The current work begins to address this task. It was found that similar, two‐stranded motifs of RNA and DNA lead to similar, but clearly different nanostructures.