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Photocatalytically Renewable Micro‐electrochemical Sensor for Real‐Time Monitoring of Cells
Author(s) -
Xu JiaQuan,
Liu YanLing,
Wang Qian,
Duo HuanHuan,
Zhang XinWei,
Li YuTao,
Huang WeiHua
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201507354
Subject(s) - graphene , electrochemistry , nanotechnology , photocatalysis , materials science , passivation , electrode , oxide , nanoparticle , biosensor , chemical engineering , chemistry , catalysis , metallurgy , organic chemistry , layer (electronics) , engineering
Electrode fouling and passivation is a substantial and inevitable limitation in electrochemical biosensing, and it is a great challenge to efficiently remove the contaminant without changing the surface structure and electrochemical performance. Herein, we propose a versatile and efficient strategy based on photocatalytic cleaning to construct renewable electrochemical sensors for cell analysis. This kind of sensor was fabricated by controllable assembly of reduced graphene oxide (RGO) and TiO 2 to form a sandwiching RGO@TiO 2 structure, followed by deposition of Au nanoparticles (NPs) onto the RGO shell. The Au NPs‐RGO composite shell provides high electrochemical performance. Meanwhile, the encapsulated TiO 2 ensures an excellent photocatalytic cleaning property. Application of this renewable microsensor for detection of nitric oxide (NO) release from cells demonstrates the great potential of this strategy in electrode regeneration and biosensing.