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A Multifunctional Subphthalocyanine Nanosphere for Targeting, Labeling, and Killing of Antibiotic‐Resistant Bacteria
Author(s) -
Roy Indranil,
Shetty Dinesh,
Hota Raghunandan,
Baek Kangkyun,
Kim Jeesu,
Kim Chulhong,
Kappert Sandro,
Kim Kimoon
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201507140
Subject(s) - bacteria , singlet oxygen , phototoxicity , chemistry , antibiotics , monomer , fluorescence , nanotechnology , covalent bond , biophysics , photoacoustic imaging in biomedicine , combinatorial chemistry , polymer , materials science , photochemistry , in vitro , oxygen , biochemistry , organic chemistry , biology , genetics , physics , quantum mechanics , optics
Developing a material that can combat antibiotic‐resistant bacteria, a major global health threat, is an urgent requirement. To tackle this challenge, we synthesized a multifunctional subphthalocyanine (SubPc) polymer nanosphere that has the ability to target, label, and photoinactivate antibiotic‐resistant bacteria in a single treatment with more than 99 % efficiency, even with a dose as low as 4.2 J cm −2 and a loading concentration of 10 n M . The positively charged nanosphere shell composed of covalently linked SubPc units can increase the local concentration of photosensitizers at therapeutic sites. The nanosphere shows superior performance compared to corresponding monomers presumably because of their enhanced water dispersibility, higher efficiency of singlet‐oxygen generation, and phototoxicity. In addition, this material is useful in fluorescence labeling of living cells and shows promise in photoacoustic imaging of bacteria in vivo.