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Chemically Locked Bicelles with High Thermal and Kinetic Stability
Author(s) -
Matsui Ryoichi,
Ohtani Masataka,
Yamada Kuniyo,
Hikima Takaaki,
Takata Masaki,
Nakamura Takashi,
Koshino Hiroyuki,
Ishida Yasuhiro,
Aida Takuzo
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201506781
Subject(s) - model lipid bilayer , thermal stability , polymerization , chemistry , chemical engineering , phase (matter) , phospholipid , materials science , polymer chemistry , membrane , polymer , organic chemistry , lipid bilayer , biochemistry , lipid bilayer phase behavior , engineering
In situ polymerization of a bicellar mixture composed of a phospholipid and polymerizable surfactants afforded unprecedented stable bicelles. The polymerized composite showed an aligned phase over a wide thermal range (25 to >90 °C) with excellent 2 H quadrupole splitting of the solvent signal, thus implying versatility as an alignment medium for NMR studies. Crosslinking of the surfactants also brought favorable effects on the kinetic stability and alignment morphology of the bicelles. This system could thus offer a new class of scaffolds for biomembrane models.