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Selective Alkenylation and Hydroalkenylation of Enol Phosphates through Direct CH Functionalization
Author(s) -
Hu XuHong,
Yang XiaoFei,
Loh TeckPeng
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201506437
Subject(s) - enol , surface modification , chemistry , phosphate , combinatorial chemistry , catalysis , organic chemistry
An efficient and selective Rh‐catalyzed direct CH functionalization reaction of enol phosphates was developed. The method is applicable to a variety of coupling partners, including activated alkenes, alkynes, and allenes, and leads to the formation of various valuable alkenylated and hydroalkenylated enol phosphates through the action of the phosphate directing group. The versatility and utility of the coupling products were demonstrated through further transformations into synthetically useful building blocks.