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Stimulation of In Vivo Antitumor Immunity with Hollow Mesoporous Silica Nanospheres
Author(s) -
Wang Xiupeng,
Li Xia,
Ito Atsuo,
Watanabe Yohei,
Sogo Yu,
Tsuji Noriko M.,
Ohno Tadao
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201506179
Subject(s) - adjuvant , in vivo , immune system , immunotherapy , immunity , cancer immunotherapy , population , mesoporous silica , cancer research , materials science , immunology , medicine , mesoporous material , chemistry , biology , environmental health , biochemistry , microbiology and biotechnology , catalysis
The use of appropriate adjuvants that support the generation of robust and long‐lasting antitumor immune responses is crucial for tumor immunotherapy owing to the immunosuppressive environment of the growing tumor. However, the most commonly used adjuvant, aluminum hydroxide, is ineffective for generating such immune responses and therefore not suitable for cancer immunotherapy. It is now shown that plain hollow mesoporous silica nanospheres markedly improve the antitumor immunity, the Th1 and Th2 immunity, and the CD4 + and CD8 + effector memory T cell population in bone marrow in vivo and may thus be used as immunoadjuvants to treat cancer in humans.