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Ultrasmall Black Phosphorus Quantum Dots: Synthesis and Use as Photothermal Agents
Author(s) -
Sun Zhengbo,
Xie Hanhan,
Tang Siying,
Yu XueFeng,
Guo Zhinan,
Shao Jundong,
Zhang Han,
Huang Hao,
Wang Huaiyu,
Chu Paul K.
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201506154
Subject(s) - photothermal therapy , exfoliation joint , sonication , black phosphorus , quantum dot , photothermal effect , nanoparticle , materials science , nanotechnology , chemical engineering , chemistry , optoelectronics , graphene , chromatography , engineering
Black phosphorus quantum dots (BPQDs) were synthesized using a liquid exfoliation method that combined probe sonication and bath sonication. With a lateral size of approximately 2.6 nm and a thickness of about 1.5 nm, the ultrasmall BPQDs exhibited an excellent NIR photothermal performance with a large extinction coefficient of 14.8 Lg −1 cm −1 at 808 nm, a photothermal conversion efficiency of 28.4 %, as well as good photostability. After PEG conjugation, the BPQDs showed enhanced stability in physiological medium, and there was no observable toxicity to different types of cells. NIR photoexcitation of the BPQDs in the presence of C6 and MCF7 cancer cells led to significant cell death, suggesting that the nanoparticles have large potential as photothermal agents.