Organomediated Enantioselective  18 F Fluorination for PET Applications | Zendy

Buckingham Faye | Zendy; Kirjavainen Anna K. | Zendy; Forsback Sarita | Zendy; Krzyczmonik Anna | Zendy; Keller Thomas | Zendy; Newington Ian M. | Zendy; Glaser Matthias | Zendy; Luthra Sajinder K. | Zendy; Solin Olof | Zendy; Gouverneur Véronique | Zendy

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Organomediated Enantioselective 18 F Fluorination for PET Applications

Author(s) -

Buckingham Faye,

Kirjavainen Anna K.,

Forsback Sarita,

Krzyczmonik Anna,

Keller Thomas,

Newington Ian M.,

Glaser Matthias,

Luthra Sajinder K.,

Solin Olof,

Gouverneur Véronique

Publication year - 2015

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201506035

Subject(s) - synthon , enantioselective synthesis , chemistry , radiochemistry , pet imaging , combinatorial chemistry , positron emission tomography , stereochemistry , organic chemistry , catalysis , nuclear medicine , medicine

The first organomediated asymmetric 18 F fluorination has been accomplished using a chiral imidazolidinone and [ 18 F]N‐fluorobenzenesulfonimide. The method provides access to enantioenriched 18 F‐labeled α‐fluoroaldehydes (>90 % ee ), which are versatile chiral 18 F synthons for the synthesis of radiotracers. The utility of this process is demonstrated with the synthesis of the PET (positron emission tomography) tracer (2 S ,4 S )‐4‐[ 18 F]fluoroglutamic acid.

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