Premium
Stable Encapsulated Air Nanobubbles in Water
Author(s) -
Wang Yu,
Liu Guojun,
Hu Heng,
Li Terry Yantian,
Johri Amer M.,
Li Xiaoyu,
Wang Jian
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201505817
Subject(s) - microbubbles , sonication , micrometer , capillary action , nanotechnology , materials science , drug delivery , ultrasound , dispersion (optics) , bubble , chemical engineering , chemistry , chromatography , composite material , optics , radiology , physics , engineering , parallel computing , computer science , medicine
The dispersion into water of nanocapsules bearing a highly hydrophobic fluorinated internal lining yielded encapsulated air nanobubbles. These bubbles, like their micrometer‐sized counterparts (microbubbles), effectively reflected ultrasound. More importantly, the nanobubbles survived under ultrasonication 100‐times longer than a commercial microbubble sample that is currently in clinical use. We justify this unprecedented stability theoretically. These nanobubbles, owing to their small size and potential ability to permeate the capillary networks of tissues, may expand the applications of microbubbles in diagnostic ultrasonography and find new applications in ultrasound‐regulated drug delivery.